My ePortfolio Register   
 

Abstract | Full HTML Article | PDF ecancer 10 688 / DOI: 10.3332/ecancer.2016.688

Clinical Study

Predictors of survival of natural killer/T-cell lymphoma, nasal type, in a non-Asian population: a single cancer centre experience

Background: Natural killer/T-cell lymphoma (NKTCL), part of T-cell and NK-cell neoplasms in the World Health Organisation (WHO) classification, is an aggressive lymphoma with poor prognosis more predominantly seen in Asian and South American countries. This study evaluates the factors associated with survival among patients with newly diagnosed NKTCL in Peru.

Methods: Information was abstracted from medical records (MR) for all NKTCL patients >13 years of age at the Instituto Nacional de Enfermedades Neoplasicas (INEN) between 2002 and 2011. The estimate of the survival curves was performed by the Kaplan-Meier method, and the difference was computed by the log-rank test.

Results: Around 226 MR were reviewed, 153 met the selection criteria, the median age was 40 years (14–84). The median progression-free survival (PFS) was 20 months, five year PFS was 42.6%, univariable analysis (UA) showed statistical significance (p < 0.05) for male sex, non-nasal primary site, advanced clinical stages, B symptoms, poor performance status, regional nodal involvement (RNI). In the multivariate analysis the only poor prognostic factors was primary non-nasal (Hazard ratio (HR) = 2.40, 95% confidence interval (CI) = 1.43– 4.02, P = 0.01). The median overall survival (OS) was 49 months, five year OS was 48.9%, UA showed statistical significance for non-nasal primary site, advanced clinical stages, B symptoms, lactate dehydrogenase (LDH) > normal, RNI and local tumour invasion. In the multivariate analysis, primary non-nasal was the only poor prognostic factor with HR = 2.57, 95% CI = 1.37–4.83, P = 0.03.

Conclusions: In Peru, OS of NKTCL is similar to other countries. This result suggests that non-nasal NKTCL is the only poor prognostic factor of OS and PFS.

Keywords: survival, predictors, natural killer/T-cell lymphoma, chemotherapy

Loading Article Metrics ... Please wait

Related articles

Clinical Study: Study of clinical, haematological and cytogenetic profile of patients with acute erythroid leukaemia

Abstract | Full Article | PDF Published: 10 Jan 2017 / DOI: 10.3332/ecancer.2017.712

Conference Report: Balancing health care needs in a changing context: nursing highlights from the 2016 European Oncology Nursing Society Congress (EONS10), 17–18 October 2016, Dublin, Ireland

Abstract | Full Article | PDF Published: 05 Jan 2017 / DOI: 10.3332/ecancer.2017.710

Special Issue: Central nervous system metastasis secondary to colorectal cancer: a retrospective cohort study of 20 cases

Abstract | Full Article | PDF | Spanish Published: 21 Dec 2016 / DOI: 10.3332/ecancer.2016.705

Conference Report: Cancer Immunotherapy: from the lab to clinical applications. Potential impact on cancer centres’ organisation

Abstract | Full Article | PDF Published: 09 Nov 2016 / DOI: 10.3332/ecancer.2016.691

Conference Report: Next generation metronomic chemotherapy—report from the Fifth Biennial International Metronomic and Anti-angiogenic Therapy Meeting, 6–8 May 2016, Mumbai

Abstract | Full Article | PDF Published: 02 Nov 2016 / DOI: 10.3332/ecancer.2016.689



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

Cancer Intelligence