My ePortfolio Register   
 

Abstract | Full HTML Article | PDF | Portuguese ecancer 10 681 / DOI: 10.3332/ecancer.2016.681

Policy

Phosphoethanolamine and the danger of unproven drugs

The use of unproven forms of therapy in cancer treatment is very common. In Brazil, the distribution by researchers to patients of an investigational agent called phophoethanolamine (PHOS) has led to a widely publicized scientific scandal. PHOS is a precursor to components of the cell membrane, with some published pre-clinical studies suggesting cytotoxic activity in cancer cells. The willingness of courts and of legislators to guarantee access to PHOS in spite of the lack of any clinical data and against the recommendations of scientific and medical organisations underscores the risks that unproven agents pose to regulatory authorities, health care systems and patients, and bears resemblance to other cases such as the controversy surrounding the approval of zidovudine for AIDS treatment by the FDA.

Keywords: phosphoethanolamine, cancer, science, Brazil, ethics

Loading Article Metrics ... Please wait

Related articles

Conference Report: Highlights from the WIN 2017 Symposium, 26–27 June 2017, Paris, France: ‘Expediting Global Innovation in Precision Cancer Medicine’

Abstract | Full Article | PDF Published: 27 Sep 2017 / DOI: 10.3332/ecancer.2017.770

Clinical Study: Expression of ERCC1, Bcl-2, Lin28a, and Ki-67 as biomarkers of response to first-line platinum-based chemotherapy in patients with high-grade extrapulmonary neuroendocrine carcinomas or small cell lung cancer

Abstract | Full Article | PDF Published: 11 Sep 2017 / DOI: 10.3332/ecancer.2017.767

Short Communication: Systemic anticancer therapy (SACT) for lung cancer and its potential for interactions with other medicines

Abstract | Full Article | PDF Published: 04 Sep 2017 / DOI: 10.3332/ecancer.2017.764

Clinical Study: Breast cancer in Angola, molecular subtypes: a first glance

Abstract | Full Article | PDF Published: 30 Aug 2017 / DOI: 10.3332/ecancer.2017.763

Review: Cancer of childhood in sub-Saharan Africa

Abstract | Full Article | PDF Published: 28 Jul 2017 / DOI: 10.3332/ecancer.2017.755



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

Cancer Intelligence