Macrophage iron recycling in triple negative breast cancer

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Published: 14 Dec 2016
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Dr Lisa Privette Vinnedge - Cincinnati Children's Hospital, Cincinnati, USA

Dr Vinnedge speaks with ecancertv at SABCS 2016 the function of the DEK protein in regulation of gene expression,  and the upregulation of tumourigenic signalling through Wnt pathways.

She describes the influence of DEK expression on macrophage behaviour, resulting in angiogenesis, immune suppression, and iron recycling to promote local cell growth.