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WIN Symposium 2017 /
Synthetic lethality as a basis to select drug combinations

26th - 27th Jun 2017

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Published: 04.07.17
Views: 175

Prof René Bernards - Netherlands Cancer Institute, Amsterdam, Holland

Prof Bernards speaks with ecancer at WIN 2017 about a staggered '1-2 punch' treatment schedule of cancer therapies, built on synthetic lethality.

In the case of BRAF melanoma, he describes the acquired MEK-resistance of tumour cells following initial treatments exposes vulnerability to histone deacetylases (HDAC) which generate a toxic level of reactive oxygen species (ROS) in cancer cells.

Prof Bernards outlines how intermittent dosing cycles with short HDAC therapies 'chasers' may prevent further resistance development and extend patient survival.

He goes on to explain the best treatment window for selectively targeting cancer cells follows an induced senescence, with animal models currently in development.

Previous conferences: highlights



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

Cancer Intelligence