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ESMO 2017 /
Pembrolizumab falls short of endpoints in KEYNOTE 40

8th - 12th Sep 2017

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Published: 11.09.17
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Dr Ezra Cohen - UC San Diego Health, San Diego, USA

Dr Cohen speaks with ecancer at the ESMO 2017 Congress about the phase III KEYNOTE-040 trial looking at pembrolizumab vs standard of care for recurrent or metastatic head and neck squamous cell carcinoma. 

While the overall survival of patients receiving PD-1 immunotherapy is improved, Dr Cohen reports that this improval falls just short of the trials threshold for statistical significance.

He also notes that grade 3-5 adverse events were reduced in the pembrolizumab arm, and that further investigations or stratification of patients by PD-L1 expression may improve on these results.

Read more about the results here.

Dr Cohen also spoke with ecancer about the SCORES trials of durvalumab combinations, here.

Previous conferences: highlights



Founding partners

European Cancer Organisation European Institute of Oncology

Founding Charities

Foundazione Umberto Veronesi Fondazione IEO Swiss Bridge

Published by

Cancer Intelligence